NMBP-29-2017
Advanced and realistic models and assays for nanomaterial hazard assessment -
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Call text (as on F&T portal)
View on F&T portalRisk assessment is often largely based on the toxicological profile of the material in question. The reason is that the costs related to hazard assessment are usually not in balance with the costs for exposure monitoring, let alone risk containment or risk mitigation. However with the very big number of new material likely to enter production and use, the usually short period between development and marketing and the increase in societal risk aversion, the classical toxicological testing paradigm so far focusing on in vivo testing is gradually but steadily shifting towards in-vitro and in-silico testing approaches. This is particularly true in the field of nanosafety where, in front of potentially thousands of different nanomaterials, economic constraints make it essential to develop and establish robust, fast and yet reliable and realistic methods that should be applied in figuring out "nanomaterials of concern".
Significant progresses have been made in assessing nanomaterial hazard. Yet, knowledge gaps remain on long-term effects (low doses, chronic exposure), both for human health and the environment. Questions also arise on the adequacy of the models used in existing in-vitro and in-silico testing and on the relevance of the exposure conditions (e.g. linked to the current understanding of the nanomaterial-biomolecule-cell interface) to correctly assess and predict real-life hazards. It is also necessary to prepare the ground for the next challenge, defining hazard profiles based on in-silico testing alone.
Scope
With a view to intelligent testing strategies (ITS) for nanomaterials, it is of high priority to develop and adopt realistic and advanced in vitro tests which have the potential to substantially improve the relevance of in-vitro approaches. Current in-vitro experiments mostly rely on established immortalized single cell lines, which often do not reflect the in-vivo situation. Therefore, new or advanced models, such as co-culture models, 3D cultures or primary cell models should be developed for relevant endpoints lacking, or having inadequate, in-vitro models. Transport through biological barriers could also be addressed, for instance with the objective of assessing the true internal dose of the materials to which living organisms are being exposed, as well as disease models or models with impaired barriers.
Low-level chronic exposure is a likely scenario as many ENMs will probably exist at very low concentrations in the environment and potentially be persistent. Thus, assays and models with low chronic exposure, elucidating toxicokinetics, different mechanisms of action and adverse outcome pathways, as well as specific disease models, should be developed and assessed against appropriate animal studies and could include for instance effects on kinetics, growth, reproduction, metabolism, and behaviour. Research could also focus on long-term, ecologically relevant, effects in realistic environmental concentrations of ENMs.
The transformations in biological or environmental matrices have been demonstrated as having potentially significant effect on the ENM tests results. Therefore, dosing with realistic exposure levels and conditions should be an integral part of the developments, taking into consideration the dynamic and complex nature of environmentally induced transformations with realistic external and internal forms and levels of exposure.
For validation purposes and to ensure that the experimental results can form a solid and meaningful basis for grouping, read-across, and modelling purposes, the testing should be performed on sets of well-defined and characterised libraries of nanomaterials and, when possible, on nanomaterials for which high-quality in-vivo data are already existing (to minimize animal testing).
Activities are expected to focus on Technology Readiness Levels 4 to 6.
This topic is particularly suitable for international cooperation.
The Commission considers that proposals requesting a contribution from the EU between EUR 10 and 13 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.
No more than one action will be funded.
Expected Impact:- The research approach should be innovative and represent a significant advance beyond the current state-of-the-art. Research should focus on provision of solutions to the long-term challenge of nanosafety and nanoregulation;
- New models and assays for use in in-vitro and in-silico testing improving prediction of chronic effects in a broad array of representative organisms and changes in ecosystem function;
- Improved predictive power of in-vitro and in-silico approaches for in vivo systems to support acceptance in a regulatory framework;
- Developed test guidelines for further standardisation, and ring testing (including guidance on design of the ring testing).
News flashes
FLASH INFORMATION ON THE CALL RESULTS2017 two-stage TOPICS
Published: 14 October 2015Deadline: 4 May 2017Available budget: 235.47 M€
The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call.The results of the evaluation are as follows:
Number of proposals submitted (including proposals transferred from or to other calls): 107Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 55Total budget requested for above-threshold proposals:343.422.171 €
We recently informed the applicants about the evaluation results for their proposals.
For questions, please contact the Research Enquiry Service.
DEADLINE (second stage) of 2017 two-stage topics: 04.05.17107 proposals were submitted in response to this call.The number of proposals for each topics is shown below:
NMBP-04-2017: 7NMBP-05-2017: 10NMBP-06-2017: 14NMBP-07-2017: 6NMBP-12-2017: 6NMBP-14-2017: 2NMBP-15-2017: 10NMBP-19-2017: 7NMBP-20-2017: 6NMBP-22-2017: 8NMBP-25-2017: 3NMBP-28-2017: 2NMBP-29-2017: 2NMBP-35-2017: 4BIOTEC-05-2017: 10BIOTEC-06-2017: 7BIOTEC-07-2017: 3
FLASH INFORMATION ON THE CALL RESULTS H2020-NMBP-2016-2017 (2017single-stage TOPICS)
Published: 14 October 2015Deadline: 19 January 2017Available budget: CSA : 8.4 M€ + NMBP-13-2017 (X-KET): 15 M€
The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call.The results of the evaluation are as follows:
CSA topicsNumber of proposals submitted (including proposals transferred from or to other calls): 16Number of inadmissible proposals: 1Number of ineligible proposals: 0Number of above-threshold proposals: 10Total budget requested for above-threshold proposals: 14,398,535.25 €
NMBP-13-2017 topicNumber of proposals submitted (including proposals transferred from or to other calls): 62Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 7Total budget requested for above-threshold proposals: 28,946,700.00 €
We recently informed the applicants about the evaluation results for their proposals.For questions, please contact the Research Enquiry Service.
Corrigendum - FLASH INFORMATION ON THE CALL RESULTS
H2020-NMBP-2016-2017 (2017 two-stage TOPICS)Please read "Deadline: 27 October 2016"
FLASH INFORMATION ON THE CALL RESULTS H2020-NMBP-2016-2017 (2017 two-stage TOPICS)
Published: 14 October 2015Deadline: 27 October 2017Available budget: 235,470,000 €
The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call. The following overall thresholds were applied:NMBP-04-2017 8,5/10NMBP-05-2017 8,5/10NMBP-06-2017 8,5/10NMBP-07-2017 8,5/10NMBP-22-2017 8,5/10NMBP-25-2017 8,5/10NMBP-28-2017 8,5/10NMBP-29-2017 8,5/10NMBP-35-2017 8,5/10NMBP-12-2017 8/10NMBP-14-2017 8/10NMBP-15-2017 8/10NMBP-19-2017 8/10NMBP-20-2017 8/10BIOTEC-05-2017 8/10BIOTEC-06-2017 8/10BIOTEC-07-2017 8/10
The results of the evaluation are as follows: Number of proposals submitted (including proposals transferred from or to other calls): 421Number of inadmissible proposals: -Number of ineligible proposals: 2Number of above-threshold proposals: 108Total budget requested for above-threshold proposals: 653,198,271 €We recently informed the applicants about the evaluation results for their proposals. Above-threshold proposals have been invited to submit a full proposal by 4 May 2017.Information on the selected projects will be published on CORDIS after that date. For questions, please contact the Research Enquiry Service.
Deadline of 2017 single-stage topics: 19.01.2017
A total of 78 proposals were submitted in response to this call. The number of proposals for each topic is shown below:
BIOTEC-08-2017: 2NMBP-13-2017: 62NMBP-16-2017: 2NMBP-31-2017: 2NMBP-34-2017: 7NMBP-37-2017: 1NMBP-38-2017: 2
Switzerland as associated country
From 1 January 2017 Switzerland is associated to the whole Horizon 2020 programme instead of the previous partial association.
This applies to all the grant agreements signed on 1 January 2017 and afterwards.
For more information please see the relevant Note on the Participant Portal.
Erratum: Deadline (first stage) of 2017 two-stage topics: 27.10.16
Deadline (first stage) of 2017 two-stage topics: 21.10.16421 proposals were submitted in response to this call.The number of proposals for each topics is shown below:
NMBP-04-2017: 51NMBP-05-2017: 53NMBP-06-2017: 81NMBP-07-2017: 21NMBP-12-2017: 10NMBP-14-2017: 3NMBP-15-2017: 27NMBP-19-2017: 25NMBP-20-2017: 15NMBP-22-2017: 35NMBP-25-2017: 6NMBP-28-2017: 8NMBP-29-2017: 14NMBP-35-2017: 27BIOTEC-05-2017: 16BIOTEC-06-2017: 18BIOTEC-07-2017: 7
Horizon 2020 Work Programme 2017 update
After the update to the Horizon 2020 Work Programme 2017 of 25 July 2016,the following updates were made:
- Open Access Data new provisions have been added for 2017 calls with an opening date on or after 26/07/2016.
- The introduction of the following parts have been modified: o BIOTEC topics under call H2020-NMBP-2016-17. o MODELLING topics under call H2020-NMBP-2016-17
- The text for evaluation criteria, scoring, threshold and procedure has been clarified.
- The text for topics NMBP-22-2017, BIOTEC-05-2017, BIOTEC-06-2017 and BIOTEC-07-2017 has been modified.
- The following two new CSA topics have been added to the call H2020-NMBP-2017: o NMBP-37-2017 Mapping a path to future supply chains o NMBP-38-2017 Support for the enhancement of the impact of PILOT projects.
- Other Action 5. Exploitation Strategy and Innovation Consultants (ESIC) has been cancelled. Other Action 6. Exploitation Strategy and Innovation Consultants (ESIC) has been changed to other action 5. Exploitation Support Services and the text has been revised.
- The following new actions have been added: o 8. Study on due diligence and risk assessment of KETs projects by investors o 9. Best practise for identifying and assessing the dual-use issues in enabling technologies research – preliminary study o 10. Addressing dual-use issues in enabling technologies research
- The indicative budget for call H2020-NMBP-2017 was increased to €253.87 million in 2017.
Flash Call Info
Call identifier: H2020-NMBP-2016-2017 (2016 Two-stage topics)Call title: Call for Nanotechnologies, Advanced materials, Biotechnology and ProductionPublished: 14 October 2015Deadline: 24 May 2016 17:00:00
Budget available: 174.08 M€
- BIOTEC-02-2016 03-2016: 32 M€
- NMBP-01-2016 + 020-2016 + 03-2016 + 23-2016 + 26-2016: 78.08 M€
- NMBP-09-2016 + 10-2016: 32 M€
- NMBP-17-2016 + 18-2016: 32M€
The Commission has completed the evaluation of the proposals submitted to the above call. The results of the evaluation are as follows:
TOPICS BIOTEC-02-2016 + 03-20016Number of proposals submitted (including proposals transferred from or to other calls): 17Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 8Total budget requested for above-threshold proposals: 48,417,925 €
NMBP-01-2016 + 020-2016 + 03-2016 + 23-2016 + 26-2016Number of proposals submitted (including proposals transferred from or to other calls): 36Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 20Total budget requested for above-threshold proposals: 116,470,292 €
NMBP-09-2016 + 10-2016Number of proposals submitted (including proposals transferred from or to other calls):16Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 6Total budget requested for above-threshold proposals: 34,039,531 €
NMBP-17-2016 + 18-2016Number of proposals submitted (including proposals transferred from or to other calls): 15Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 6Total budget requested for above-threshold proposals: 32,301,327 €
We recently informed the applicants about the evaluation results for their proposals.
The number of proposals that can finally be funded depends on the available budget and the formal approval of grant agreements by the Commission.
It is expected that the first grant agreements will be signed by November 2016.
Information on the selected projects will be published on CORDIS after that date.http://cordis.europa.eu/projects/home_en.html
In case of questions, please contact the Research Enquiry Servicehttp://ec.europa.eu/research/enquiries
An overview of the following evaluation results (flash call info) is now available under the tab Topic conditions and documents:
- 2016 NMBP single stage topics
- 2016 NMBP two-stage topics (first stage results)
Deadline of 2016 single stage topics: 21.01.1638 proposals were submitted in response to this call.The number of proposals for each topics is shown below:
Type of Action: CSA
BIOTEC-04: 3NMBP-24: 1NMBP-27: 2 NMBP-30: 1NMBP-31: 2NMBP-32: 1NMBP-33: 4NMBP-36: 1
Type of Action ERANET-co-FUND
BIOTEC-01: 2NMBP-11: 1NMBP-21: 1
Type of Action RIA (Green Vehicles topic)
NMBP-08: 19
Deadline (first stage) of 2016 two-stage topics: 08.12.15305 proposals were submitted in response to this call.The number of proposals for each topics is shown below:
NMBP-01-2016: 25NMBP-02-2016: 17NMBP-03-2016: 37NMBP-09-2016: 17NMBP-10-2016: 61NMBP-17-2016: 42NMBP-18-2016: 4NMBP-23-2016: 9NMBP-26-2016: 17BIOTEC-02-2016: 47BIOTEC-03-2016: 29
Opening date: 2016-05-11 (9 years ago)
Closing date: 2016-10-27 (9 years ago)
Procedure: two-stage
Budget: 116,460,000
Expected grants: not specified
This call topic has been appended 18 times by the EC with news.
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2017-07-06
flash information on the call results201... -
2017-05-17
deadline (second stage) of 2017 two-stag... -
2017-04-27
flash information on the call results h2... -
2017-02-07
corrigendum - flash information on the c... -
2017-01-30
flash information on the call results h2... -
2017-01-24
deadline of 2017 single-stage topics: 19... -
2017-01-11
switzerland as associated countryfrom 1... -
2016-11-08
erratum: deadline (first stage) of 2017... -
2016-11-08
deadline (first stage) of 2017 two-stage... -
2016-09-20
the submission session is now available... -
2016-09-20
the submission session is now available... -
2016-08-03
the submission session is now available... -
2016-08-03
the submission session is now available... -
2016-07-25
horizon 2020 work programme 2017 updatea... -
2016-07-12
flash call infocall identifier: h2020-nm... -
2016-04-19
an overview of the following evaluation... -
2016-01-25
deadline of 2016 single stage topics: 21... -
2015-12-14
deadline (first stage) of 2016 two-stage...
H2020-NMBP-2016-2017
Call topics are often grouped together in a call. Sometimes this is for a thematic reason, but often it is also for practical reasons.
There are 46 other topics in this call:
- BIOTEC-01-2016
- BIOTEC-02-2016
- BIOTEC-03-2016
- BIOTEC-04-2016
- BIOTEC-05-2017
- BIOTEC-06-2017
- BIOTEC-07-2017
- BIOTEC-08-2017
- NMBP-01-2016
- NMBP-02-2016
- NMBP-03-2016
- NMBP-04-2017
- NMBP-05-2017
- NMBP-06-2017
- NMBP-07-2017
- NMBP-08-2016
- NMBP-09-2016
- NMBP-10-2016
- NMBP-11-2016
- NMBP-12-2017
- NMBP-13-2017
- NMBP-14-2017
- NMBP-15-2017
- NMBP-16-2017
- NMBP-17-2016
- NMBP-18-2016
- NMBP-19-2017
- NMBP-20-2017
- NMBP-21-2016
- NMBP-22-2017
- NMBP-23-2016
- NMBP-24-2016
- NMBP-25-2017
- NMBP-26-2016
- NMBP-27-2016
- NMBP-28-2017
- NMBP-30-2016
- NMBP-31-2016
- NMBP-31-2017
- NMBP-32-2016
- NMBP-33-2016
- NMBP-34-2017
- NMBP-35-2017
- NMBP-36-2016
- NMBP-37-2017
- NMBP-38-2017
Showing the latest information. Found 1 version of this call topic in the F&T portal.
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- 2024-03-30_14-22-23
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Project information comes from CORDIS (for Horizon 2020 and Horizon Europe) and will be sourced from F&T Portal (for Digital Europe projects)