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NMBP-10-2016

Nanoformulation of biologicals -

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Call text (as on F&T portal)

View on F&T portal
Specific Challenge:

Many biomolecules (e.g. proteins, peptides, nucleic acid, enzymes), in opposition to classical small molecules, have demonstrated interesting therapeutic activities in vitro. However, they are too often not druggable because once in pre-clinical in vivo development, they show disappointing loss of efficacy and/or unacceptable toxicity. For example, a high in vitro efficacy of a therapeutic biomolecule can disappointedly become low in vivo, because the biomolecule is processed by the immune system or by enzymes of the host before reaching its targeted tissue. Nanotechnology represents a promising opportunity to overcome these drawbacks. Indeed, the formulation of nanocarriers containing biomolecules ('biologicals') for drug/vaccine delivery can greatly improve their in vivo efficacy and/or decrease their toxicity and provide the capability to cross biological barriers (e.g. intestinal, blood-brain barrier, nasal, ocular, pulmonary, skin).

Scope

This call addresses nanoformulation of biologicals (like proteins, peptides, nucleic acids and enzymes). With an appropriate formulation the biologicals can be effectively transported through the relevant biological barriers to the targeted organs, tissues and cells.

Formulation of nanomedicines has in general been empirical and often produced in an amorphous or undefined structure, which produces regulatory and manufacturing control issues. The aim of the research is to achieve excellent quality control of the assembly by using self-assembling systems. The resulting processes should provide a high degree of control over the physico-chemical parameters like shape, size and chemical composition while incorporating non-Lipinski molecules such as nucleics acids, proteins or peptides. Characterisation aspects of the nanoformulations therefore have to be properly addressed. The benefit will be easier manufacturing and process control, as well as optimised nanoformulation of biologicals with tailored transport through biological barriers.

Projects will develop a nanoformulation of biomolecules to provide a solid pre-clinical proof of concept, address scale-up to the quantities needed for late pre-clinical and clinical study and prepare for future clinical testing. Partners will also have to describe how the various barriers for advancing their new therapy to clinical application will be overcome; they will especially take into account the medical regulatory requirements and the scale-up production for clinical study. As relevant, the proposed activities should address sex and gender specific aspects[1].

The clinical focus should be notably on age related diseases, neglected diseases and rare diseases or inflammatory diseases, but excluding cancer and infectious diseases.

Activities are expected to commence at Technology Readiness Levels 3 /4 and reach 5/6.

This topic is particularly suitable for SMEs.

The Commission considers that proposals requesting a contribution from the EU between EUR 5 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected Impact:
  • Developments of new solutions for the particularly needed delivery of biologicals;
  • Radical improvement of therapy through the development of new nanoformulation solutions for the delivery of biologicals;
  • Foster the translation of nanoformulation of biomolecules towards clinical development / application;
  • Improvement of the competitiveness of the European healthcare industry through accelerated introduction of new nanotechnology enabled therapies;
  • Improved understanding by academics and research organisations of the requirements of the pharmaceutical and medical devices industry and of medical regulators.

Proposals should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.

Cross-cutting Priorities:

Gender

[1]See definition of the 'gender dimension approach' in the introduction of this Work Programme part.

News flashes

2017-07-06

FLASH INFORMATION ON THE CALL RESULTS2017 two-stage TOPICS

Published: 14 October 2015Deadline: 4 May 2017Available budget: 235.47 M€

The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call.The results of the evaluation are as follows:

Number of proposals submitted (including proposals transferred from or to other calls): 107Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 55Total budget requested for above-threshold proposals:343.422.171 €

We recently informed the applicants about the evaluation results for their proposals.

For questions, please contact the Research Enquiry Service.

2017-05-17

DEADLINE (second stage) of 2017 two-stage topics: 04.05.17107 proposals were submitted in response to this call.The number of proposals for each topics is shown below:

NMBP-04-2017: 7NMBP-05-2017: 10NMBP-06-2017: 14NMBP-07-2017: 6NMBP-12-2017: 6NMBP-14-2017: 2NMBP-15-2017: 10NMBP-19-2017: 7NMBP-20-2017: 6NMBP-22-2017: 8NMBP-25-2017: 3NMBP-28-2017: 2NMBP-29-2017: 2NMBP-35-2017: 4BIOTEC-05-2017: 10BIOTEC-06-2017: 7BIOTEC-07-2017: 3

2017-04-27

FLASH INFORMATION ON THE CALL RESULTS H2020-NMBP-2016-2017 (2017single-stage TOPICS)

Published: 14 October 2015Deadline: 19 January 2017Available budget: CSA : 8.4 M€ + NMBP-13-2017 (X-KET): 15 M€

The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call.The results of the evaluation are as follows:

CSA topicsNumber of proposals submitted (including proposals transferred from or to other calls): 16Number of inadmissible proposals: 1Number of ineligible proposals: 0Number of above-threshold proposals: 10Total budget requested for above-threshold proposals: 14,398,535.25 €

NMBP-13-2017 topicNumber of proposals submitted (including proposals transferred from or to other calls): 62Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 7Total budget requested for above-threshold proposals: 28,946,700.00 €

We recently informed the applicants about the evaluation results for their proposals.For questions, please contact the Research Enquiry Service.

2017-02-07

Corrigendum - FLASH INFORMATION ON THE CALL RESULTS

H2020-NMBP-2016-2017 (2017 two-stage TOPICS)Please read "Deadline: 27 October 2016"

2017-01-30

FLASH INFORMATION ON THE CALL RESULTS H2020-NMBP-2016-2017 (2017 two-stage TOPICS)

Published: 14 October 2015Deadline: 27 October 2017Available budget: 235,470,000 €

The Commission has now completed the evaluation of the proposals submitted to the above-mentioned call. The following overall thresholds were applied:NMBP-04-2017 8,5/10NMBP-05-2017 8,5/10NMBP-06-2017 8,5/10NMBP-07-2017 8,5/10NMBP-22-2017 8,5/10NMBP-25-2017 8,5/10NMBP-28-2017 8,5/10NMBP-29-2017 8,5/10NMBP-35-2017 8,5/10NMBP-12-2017 8/10NMBP-14-2017 8/10NMBP-15-2017 8/10NMBP-19-2017 8/10NMBP-20-2017 8/10BIOTEC-05-2017 8/10BIOTEC-06-2017 8/10BIOTEC-07-2017 8/10

The results of the evaluation are as follows: Number of proposals submitted (including proposals transferred from or to other calls): 421Number of inadmissible proposals: -Number of ineligible proposals: 2Number of above-threshold proposals: 108Total budget requested for above-threshold proposals: 653,198,271 €We recently informed the applicants about the evaluation results for their proposals. Above-threshold proposals have been invited to submit a full proposal by 4 May 2017.Information on the selected projects will be published on CORDIS after that date. For questions, please contact the Research Enquiry Service.

2017-01-24

Deadline of 2017 single-stage topics: 19.01.2017

A total of 78 proposals were submitted in response to this call. The number of proposals for each topic is shown below:

BIOTEC-08-2017: 2NMBP-13-2017: 62NMBP-16-2017: 2NMBP-31-2017: 2NMBP-34-2017: 7NMBP-37-2017: 1NMBP-38-2017: 2

2016-11-08

Erratum: Deadline (first stage) of 2017 two-stage topics: 27.10.16

2016-11-08

Deadline (first stage) of 2017 two-stage topics: 21.10.16421 proposals were submitted in response to this call.The number of proposals for each topics is shown below:

NMBP-04-2017: 51NMBP-05-2017: 53NMBP-06-2017: 81NMBP-07-2017: 21NMBP-12-2017: 10NMBP-14-2017: 3NMBP-15-2017: 27NMBP-19-2017: 25NMBP-20-2017: 15NMBP-22-2017: 35NMBP-25-2017: 6NMBP-28-2017: 8NMBP-29-2017: 14NMBP-35-2017: 27BIOTEC-05-2017: 16BIOTEC-06-2017: 18BIOTEC-07-2017: 7

2016-09-20
The submission session is now available for: NMBP-13-2017(RIA)
2016-09-20
The submission session is now available for: NMBP-16-2017(CSA), NMBP-37-2017(CSA), NMBP-31-2017(CSA), NMBP-38-2017(CSA), BIOTEC-08-2017(CSA), NMBP-34-2017(CSA)
2016-08-03
The submission session is now available for: NMBP-06-2017(RIA), NMBP-07-2017(RIA), NMBP-05-2017(IA), NMBP-28-2017(RIA), NMBP-19-2017(RIA), NMBP-14-2017(RIA), NMBP-04-2017(RIA), NMBP-15-2017(RIA), NMBP-25-2017(IA), NMBP-12-2017(RIA), NMBP-22-2017(RIA), NMBP-20-2017(IA), NMBP-29-2017(RIA), NMBP-35-2017(RIA)
2016-08-03
The submission session is now available for: BIOTEC-06-2017(IA), BIOTEC-05-2017(RIA), BIOTEC-07-2017(RIA)
2016-07-25

Horizon 2020 Work Programme 2017 update

After the update to the Horizon 2020 Work Programme 2017 of 25 July 2016,the following updates were made:

  • Open Access Data new provisions have been added for 2017 calls with an opening date on or after 26/07/2016.
  • The introduction of the following parts have been modified: o BIOTEC topics under call H2020-NMBP-2016-17. o MODELLING topics under call H2020-NMBP-2016-17
  • The text for evaluation criteria, scoring, threshold and procedure has been clarified.
  • The text for topics NMBP-22-2017, BIOTEC-05-2017, BIOTEC-06-2017 and BIOTEC-07-2017 has been modified.
  • The following two new CSA topics have been added to the call H2020-NMBP-2017: o NMBP-37-2017 Mapping a path to future supply chains o NMBP-38-2017 Support for the enhancement of the impact of PILOT projects.
  • Other Action 5. Exploitation Strategy and Innovation Consultants (ESIC) has been cancelled. Other Action 6. Exploitation Strategy and Innovation Consultants (ESIC) has been changed to other action 5. Exploitation Support Services and the text has been revised.
  • The following new actions have been added: o 8. Study on due diligence and risk assessment of KETs projects by investors o 9. Best practise for identifying and assessing the dual-use issues in enabling technologies research – preliminary study o 10. Addressing dual-use issues in enabling technologies research
  • The indicative budget for call H2020-NMBP-2017 was increased to €253.87 million in 2017.

2016-07-12

Flash Call Info

Call identifier: H2020-NMBP-2016-2017 (2016 Two-stage topics)Call title: Call for Nanotechnologies, Advanced materials, Biotechnology and ProductionPublished: 14 October 2015Deadline: 24 May 2016 17:00:00

Budget available: 174.08 M€

  • BIOTEC-02-2016 03-2016: 32 M€
  • NMBP-01-2016 + 020-2016 + 03-2016 + 23-2016 + 26-2016: 78.08 M€
  • NMBP-09-2016 + 10-2016: 32 M€
  • NMBP-17-2016 + 18-2016: 32M€

The Commission has completed the evaluation of the proposals submitted to the above call. The results of the evaluation are as follows:

TOPICS BIOTEC-02-2016 + 03-20016Number of proposals submitted (including proposals transferred from or to other calls): 17Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 8Total budget requested for above-threshold proposals: 48,417,925 €

NMBP-01-2016 + 020-2016 + 03-2016 + 23-2016 + 26-2016Number of proposals submitted (including proposals transferred from or to other calls): 36Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 20Total budget requested for above-threshold proposals: 116,470,292 €

NMBP-09-2016 + 10-2016Number of proposals submitted (including proposals transferred from or to other calls):16Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 6Total budget requested for above-threshold proposals: 34,039,531 €

NMBP-17-2016 + 18-2016Number of proposals submitted (including proposals transferred from or to other calls): 15Number of inadmissible proposals: 0Number of ineligible proposals: 0Number of above-threshold proposals: 6Total budget requested for above-threshold proposals: 32,301,327 €

We recently informed the applicants about the evaluation results for their proposals.

The number of proposals that can finally be funded depends on the available budget and the formal approval of grant agreements by the Commission.

It is expected that the first grant agreements will be signed by November 2016.

Information on the selected projects will be published on CORDIS after that date.http://cordis.europa.eu/projects/home_en.html

In case of questions, please contact the Research Enquiry Servicehttp://ec.europa.eu/research/enquiries

2016-04-19

An overview of the following evaluation results (flash call info) is now available under the tab Topic conditions and documents:

  • 2016 NMBP single stage topics
  • 2016 NMBP two-stage topics (first stage results)
2016-01-25

Deadline of 2016 single stage topics: 21.01.1638 proposals were submitted in response to this call.The number of proposals for each topics is shown below:

Type of Action: CSA

BIOTEC-04: 3NMBP-24: 1NMBP-27: 2 NMBP-30: 1NMBP-31: 2NMBP-32: 1NMBP-33: 4NMBP-36: 1

Type of Action ERANET-co-FUND

BIOTEC-01: 2NMBP-11: 1NMBP-21: 1

Type of Action RIA (Green Vehicles topic)

NMBP-08: 19

2015-12-14

Deadline (first stage) of 2016 two-stage topics: 08.12.15305 proposals were submitted in response to this call.The number of proposals for each topics is shown below:

NMBP-01-2016: 25NMBP-02-2016: 17NMBP-03-2016: 37NMBP-09-2016: 17NMBP-10-2016: 61NMBP-17-2016: 42NMBP-18-2016: 4NMBP-23-2016: 9NMBP-26-2016: 17BIOTEC-02-2016: 47BIOTEC-03-2016: 29

call topic details
Call status: Closed
Opening date: 2015-10-15 (10 years ago)
Closing date: 2015-12-08 (10 years ago)
Procedure: two-stage

Budget: 32,000,000
Expected grants: not specified
News flashes

This call topic has been appended 17 times by the EC with news.

  • 2017-07-06
    flash information on the call results201...
  • 2017-05-17
    deadline (second stage) of 2017 two-stag...
  • 2017-04-27
    flash information on the call results h2...
  • 2017-02-07
    corrigendum - flash information on the c...
  • 2017-01-30
    flash information on the call results h2...
  • 2017-01-24
    deadline of 2017 single-stage topics: 19...
  • 2016-11-08
    erratum: deadline (first stage) of 2017...
  • 2016-11-08
    deadline (first stage) of 2017 two-stage...
  • 2016-09-20
    the submission session is now available...
  • 2016-09-20
    the submission session is now available...
  • 2016-08-03
    the submission session is now available...
  • 2016-08-03
    the submission session is now available...
  • 2016-07-25
    horizon 2020 work programme 2017 updatea...
  • 2016-07-12
    flash call infocall identifier: h2020-nm...
  • 2016-04-19
    an overview of the following evaluation...
  • 2016-01-25
    deadline of 2016 single stage topics: 21...
  • 2015-12-14
    deadline (first stage) of 2016 two-stage...
Call

H2020-NMBP-2016-2017

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